Medscape prostate cancer treatment protocols. Cancer aggressive definition

medscape prostate cancer treatment protocols

With the increasing development of dedicated devices for peripheral lesions, more interventional cardiologists have become interested in peripheral interventions.

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Other drug-eluting stents that were tested in previous trials failed, however, to show significant differences in outcome, compared with those of bare-metal stenting. This trial was different.

In one major finding of the multitiered study, patency rates at 12 months were And in a head-to-head comparison of provisional stenting, the patency rate was Michael D. The trial enrolled patients at 55 sites in the United States, Germany, and Japan.

Patients had symptomatic disease of the above-the-knee femoropopliteal artery most were moderately to severely symptomaticas well as lesions up to 14 cm.

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The average lesion length was 6. In the first of two randomization protocols, patients were randomized to treatment with either conventional percutaneous transluminal angioplasty PTA or with the Zilver PTX stent, a self-expanding nitinol stent with a polymer-free paclitaxel coating.

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After 1 year, Patency was defined as peak systolic velocity ratio less than 2. However, PTA failed to restore primary patency in approximately half of the patients in the PTA group — a rate seen in other trials.

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In this comparison of provisional stenting, month patency rates were In other words, the month restenosis rates were Dake of Stanford California University. The primary safety end point was month event-free survival, which included freedom from amputation, target lesion revascularization, and significant worsening of claudication.

Event-free survival was Patients in the trial were on a dual antiplatelet regimen for at least 2 months.

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Dake said. Investigators in the current randomized trial were limited, per the U. Food and Drug Administration—approved study protocol, to treat lesions that were no longer than 14 cm, Dr. Clinical outcomes, which will be medscape prostate cancer treatment protocols later, mirror the patency findings, Dr.

There will be ongoing follow-up through 5 years. William A. Both studies failed to show any real efficacy at reducing restenosis.

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The Zilver PTX stent lacks a durable polymer and delivers paclitaxel rather than a limus drug, which raises questions about the causal mechanisms for its unprecedented success, Dr. Gray said. There are also questions about how its effectiveness in the shorter lesions in this trial can be extrapolated to real-world lesion lengths of 20 cm and even 30 cm.

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Nevertheless, he noted, this positive trial is a critically important proof of concept, and potentially groundbreaking in the way superficial femoral artery disease and popliteal treatment will be viewed from now on.